Pair Name	Vitamin C, Erastin
Disease Info	[ICD-11: 2C10.Z]	Pancreatic cancer		Investigative
Biological Phenomena	Induction-->Ferroptosis
Gene Regulation	Up-regulation	Expression	SLC2A1	hsa6513
	Up-regulation	Phosphorylation	PRKAA1	hsa5562
	Up-regulation	Expression	NFE2L2	hsa4780
	Up-regulation	Expression	HMOX1	hsa3162
	Up-regulation	Expression	NCOA4	hsa8031
	Down-regulation	Expression	CP	hsa1356
	Down-regulation	Expression	SLC7A11	hsa23657
	Up-regulation	Expression	NFE2L2	hsa4780
In Vitro Model	PaTu 8988s	Pancreatic adenocarcinoma	Homo sapiens (Human)	CVCL_1846
	BxPC-3	Pancreatic ductal adenocarcinoma	Homo sapiens (Human)	CVCL_0186
In Vivo Model	Panc02 cells (1×10⁵ cells/site) were transfected and subcutaneously injected into 4-week-old C57BL/6 mice to generate xenografts.
Result	The combination of erastin and vitamin C exerts a synergistic effect of classical and nonclassical modes to induce ferroptosis in PC cells, which may provide a promising therapeutic strategy for PC.